苦しかったらギブアップして、お姉さんのお願いを聞きなさいっ。

painful; difficult; agonizing; needy; tight (budget); straitened (circumstances); forced (smile, joke); lame (excuse); strained (interpretation); awkward (situation); painful (position); (after masu stem) hard to do; unpleasant

give up

to do; to cause to become; to make (into); to turn (into); to serve as; to act as; to work as; to wear (clothes, a facial expression, etc.); to judge as being; to view as being; to think of as; to treat as; to use as; to decide on; to choose; to be sensed (of a smell, noise, etc.); to be (in a state, condition, etc.); to be worth; to cost; to pass (of time); to elapse; verbalizing suffix (applies to nouns noted in this dictionary with the part of speech "vs"); creates a humble verb (after a noun prefixed with "o" or "go"); to be just about to; to be just starting to; to try to; to attempt to

honorific/polite/humble prefix

elder sister; (vocative) young lady; miss (referring to a waitress, etc.); ma'am (used by geisha to refer to their superiors)

indicates possessive; nominalizes verbs and adjectives; substitutes for "ga" in subordinate phrases; (at sentence-end, falling tone) indicates a confident conclusion; (at sentence-end) indicates emotional emphasis; (at sentence-end, rising tone) indicates question

request; wish; please

indicates direct object of action; indicates subject of causative expression; indicates an area traversed; indicates time (period) over which action takes place; indicates point of departure or separation of action; indicates object of desire, like, hate, etc.

to hear; to listen (e.g. to music); to ask; to enquire; to query; to learn of; to hear about; to follow (advice); to comply with; to smell (esp. incense); to sample fragrance

earthquake

to do up (hair); to braid; to fasten; to fix