それは命にかかわる問題だ。

that (indicating an item or person near the listener, the action of the listener, or something on their mind); it; that time; then; there (indicating a place near the listener); you

topic marker particle; indicates contrast with another option (stated or unstated); adds emphasis

life; life force; lifetime; lifespan; most important thing; foundation; core; paired tattoos of the "life" kanji on the upper arms of a man and woman (indicating unwavering love); fate; destiny; karma

at (place, time); in; on; during; to (direction, state); toward; into; for (purpose); because of (reason); for; with; by; from; as (i.e. in the role of); per; in; for; a (e.g. "once a month"); and; in addition to; if; although

to be affected; to be influenced; to be concerned with; to have to do with; to stick to (opinions)

question (e.g. on a test); problem; problem (e.g. societal, political); question; issue; subject (e.g. of research); case; matter; question (i.e. doubt); public discussion; controversy; trouble; problem; inconvenience; difficulty

be; is; indicates past or completed action; indicates light imperative