手は汚れていませんか。

hand; arm; forepaw; foreleg; handle; hand; worker; help; trouble; care; effort; means; way; trick; move; technique; workmanship; hand; handwriting; kind; type; sort; one's hands; one's possession; ability to cope; hand (of cards); direction; move (in go, shogi, etc.)

topic marker particle; indicates contrast with another option (stated or unstated); adds emphasis

to get dirty; to become dirty; to become sullied; to become corrupted; to lose one's chastity

indicates a question (sometimes rhetorical); or; whether or not; some- (e.g. something, someone); indicates doubt, uncertainty, etc.; emphatic prefix; suffix forming adjectives or adverbs; in that way