What's the matter?
question (e.g. on a test); problem; problem (e.g. societal, political); question; issue; subject (e.g. of research); case; matter; question (i.e. doubt); public discussion; controversy; trouble; problem; inconvenience; difficulty
but; however; though; nevertheless; still; yet; even so; even; however; no matter how; even if; even though; ... or something; either ... or ...; neither ... nor ...; pseudo-; quack; in-name-only; for lack of anything better to do