彼らは子供のときからお互いに知っている。

they (usually male); them

topic marker particle; indicates contrast with another option (stated or unstated); adds emphasis

child; children

indicates possessive; nominalizes verbs and adjectives; substitutes for "ga" in subordinate phrases; (at sentence-end, falling tone) indicates a confident conclusion; (at sentence-end) indicates emotional emphasis; (at sentence-end, rising tone) indicates question

regular (stops at every station) Jouetsu-line Shinkansen

from (e.g. time, place, numerical quantity); since; from (originator); by; because; since; out of (constituent, part); through (e.g. window, vestibule); after; since

mutual; reciprocal; each other

at (place, time); in; on; during; to (direction, state); toward; into; for (purpose); because of (reason); for; with; by; from; as (i.e. in the role of); per; in; for; a (e.g. "once a month"); and; in addition to; if; although

to be aware of; to know; to be conscious of; to cognize; to cognise; to notice; to feel; to understand; to comprehend; to grasp; to remember; to be acquainted with (a procedure); to experience; to go through; to learn; to be acquainted with (a person); to get to know; to concern