彼女のいいわけは全く意味をなさない。

she; her; her; girlfriend; sweetheart

indicates possessive; nominalizes verbs and adjectives; substitutes for "ga" in subordinate phrases; (at sentence-end, falling tone) indicates a confident conclusion; (at sentence-end) indicates emotional emphasis; (at sentence-end, rising tone) indicates question

excuse; explanation

topic marker particle; indicates contrast with another option (stated or unstated); adds emphasis

really; truly; entirely; completely; wholly; perfectly; indeed; good grief (expression of exasperation)

meaning; significance

indicates direct object of action; indicates subject of causative expression; indicates an area traversed; indicates time (period) over which action takes place; indicates point of departure or separation of action; indicates object of desire, like, hate, etc.

to build up; to establish; to form; to become (a state); to accomplish; to achieve; to succeed in; to change into; to do; to perform; to intend to; to attempt; to try