そこに問題がある。

there (place relatively near listener); there (place just mentioned); that place; then (of some incident just spoken of); that (of point just raised); you

at (place, time); in; on; during; to (direction, state); toward; into; for (purpose); because of (reason); for; with; by; from; as (i.e. in the role of); per; in; for; a (e.g. "once a month"); and; in addition to; if; although

question (e.g. on a test); problem; problem (e.g. societal, political); question; issue; subject (e.g. of research); case; matter; question (i.e. doubt); public discussion; controversy; trouble; problem; inconvenience; difficulty

indicates sentence subject (occasionally object); indicates possessive (esp. in literary expressions); but; however; still; and

to be (usu. of inanimate objects); to exist; to live; to have; to be located; to be equipped with; to happen; to come about