あなたがここを去るとは残念だ。

you (referring to someone of equal or lower status); dear (what a wife calls a husband)

indicates sentence subject (occasionally object); indicates possessive (esp. in literary expressions); but; however; still; and

here (place physically close to the speaker, place pointed by the speaker while explaining); this place; these last (followed by a duration noun and a past sentence: time period before the present time of the speaker); these next ... (followed by a duration noun and a non past sentence: time period after the present time of the speaker); the next ...

indicates direct object of action; indicates subject of causative expression; indicates an area traversed; indicates time (period) over which action takes place; indicates point of departure or separation of action; indicates object of desire, like, hate, etc.

to leave; to go away; to pass; to elapse; to be distant; to send away; to drive off; to divorce; ... completely; last ... (e.g. "last April")

if; when; and; with; particle used for quoting (with speech, thoughts, etc.); quoting particle; promoted pawn; indicates question (sentence end)

topic marker particle; indicates contrast with another option (stated or unstated); adds emphasis

deplorable; bad luck; regret; disappointment

be; is; indicates past or completed action; indicates light imperative