あなたの手は洗う必要がある。

you (referring to someone of equal or lower status); dear (what a wife calls a husband)

indicates possessive; nominalizes verbs and adjectives; substitutes for "ga" in subordinate phrases; (at sentence-end, falling tone) indicates a confident conclusion; (at sentence-end) indicates emotional emphasis; (at sentence-end, rising tone) indicates question

hand; arm; forepaw; foreleg; handle; hand; worker; help; trouble; care; effort; means; way; trick; move; technique; workmanship; hand; handwriting; kind; type; sort; one's hands; one's possession; ability to cope; hand (of cards); direction; move (in go, shogi, etc.)

topic marker particle; indicates contrast with another option (stated or unstated); adds emphasis

to wash; to investigate

necessary; needed; essential; indispensable; necessity; need; requirement

indicates sentence subject (occasionally object); indicates possessive (esp. in literary expressions); but; however; still; and

to be (usu. of inanimate objects); to exist; to live; to have; to be located; to be equipped with; to happen; to come about