あなたはそれをどう説明しますか。

you (referring to someone of equal or lower status); dear (what a wife calls a husband)

topic marker particle; indicates contrast with another option (stated or unstated); adds emphasis

that (indicating an item or person near the listener, the action of the listener, or something on their mind); it; that time; then; there (indicating a place near the listener); you

indicates direct object of action; indicates subject of causative expression; indicates an area traversed; indicates time (period) over which action takes place; indicates point of departure or separation of action; indicates object of desire, like, hate, etc.

how; in what way; how about

explanation; exposition

indicates a question (sometimes rhetorical); or; whether or not; some- (e.g. something, someone); indicates doubt, uncertainty, etc.; emphatic prefix; suffix forming adjectives or adverbs; in that way