このハンカチで鼻をかみなさい。

this (something or someone close to the speaker (including the speaker), or ideas expressed by the speaker)

handkerchief

indicates location of action; at; in; indicates time of action; indicates means of action; cause of effect; by; and then; so; indicates continuing action; indicates certainty, emphasis, etc.

nose

indicates direct object of action; indicates subject of causative expression; indicates an area traversed; indicates time (period) over which action takes place; indicates point of departure or separation of action; indicates object of desire, like, hate, etc.

god; deity; divinity; spirit; kami; incredible; fantastic; emperor of Japan; thunder

to do