この部の責任者は誰か。

this (something or someone close to the speaker (including the speaker), or ideas expressed by the speaker)

department (in an organization); division; bureau; club; part; component; element; category; counter for copies of a newspaper or magazine

indicates possessive; nominalizes verbs and adjectives; substitutes for "ga" in subordinate phrases; (at sentence-end, falling tone) indicates a confident conclusion; (at sentence-end) indicates emotional emphasis; (at sentence-end, rising tone) indicates question

person in charge (including a supervisory role for other staff); person responsible for ...; responsible party; supervisor; manager

topic marker particle; indicates contrast with another option (stated or unstated); adds emphasis

who

indicates a question (sometimes rhetorical); or; whether or not; some- (e.g. something, someone); indicates doubt, uncertainty, etc.; emphatic prefix; suffix forming adjectives or adverbs; in that way