これは水に溶けない。

this (indicating an item near the speaker, the action of the speaker, or the current topic); this person (usu. indicating someone in one's in-group); now; here; I (me); certainly

topic marker particle; indicates contrast with another option (stated or unstated); adds emphasis

water (esp. cool, fresh water, e.g. drinking water); fluid (esp. in an animal tissue); liquid; flood; floodwaters; water offered to wrestlers just prior to a bout; break granted to wrestlers engaged in a prolonged bout

at (place, time); in; on; during; to (direction, state); toward; into; for (purpose); because of (reason); for; with; by; from; as (i.e. in the role of); per; in; for; a (e.g. "once a month"); and; in addition to; if; although

to melt; to thaw; to fuse; to dissolve